Age- and alcohol-related differences in adolescent neurometabolite levels
Published in Alcohol, Clinical and Experimental Research, 2026
Adolescence is a critical period for neurometabolic maturation and is typically when alcohol use is initiated. Using 3T magnetic resonance spectroscopy in 84 adolescents (ages = 17–22), we observed age-related increases in metabolites supporting neuronal health, membrane synthesis, glial function, inhibitory neurotransmission, and decreases in excitatory neurotransmission. More alcohol use was associated with lower levels of a metabolite linked to neuronal health. These findings clarify developmental patterns of neurometabolites and highlight a potential biomarker for early alcohol-related disruption during adolescence.
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